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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $2,270 | 1-2 weeks | |
50 mg | $2,980 | 1-2 weeks | |
100 mg | $4,000 | 1-2 weeks |
Description | SB 243213 hydrochloride is an orally active, selective, high-affinity antagonist of the 5-hydroxytryptamine (5-HT)2C receptor (pKi of 9.37 and pKb of 9.8), with an improved anxiolytic profile and potential for treating schizophrenia and motor disorders. |
In vitro | SB 243213 hydrochloride showed little affinity with pKi less than 6 for cloned human 5-HT1A, 5-HT1B, 5-HT1E, 5- HT1F and 5-HT7 receptors. It showed weak affinity (pKi<6.5) for the cloned human 5-HT1D and D3 receptors and moderate affinity (pKi=6.7) for the cloned human D2 receptor. |
In vivo | SB 243213 hydrochloride (0.3 mg/kg; p.o.; 1 h pre-test) significantly increases time spent in social interaction.SB 243213 hydrochloride (0.1-10 mg/kg, p.o. 1 h pre-test) dose-dependently and significantly increases the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box. |
Molecular Weight | 464.87 |
Formula | C22H20ClF3N4O2 |
Cas No. | 200940-23-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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